Apoptosis and its related diseases. Mechanism of apoptosis induced by the Bax protein.
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چکیده
منابع مشابه
Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation.
The hypoxic environment in solid tumors results from oxygen consumption by rapid proliferation of tumor cells. Hypoxia has been shown to facilitate the survival of tumor cells and to be a cause of malignant transformation. Hypoxia also is well known to attenuate the therapeutic activity of various therapies in cancer management. These observations indicate that hypoxia plays a critical role in ...
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15 صفحه اولThe Characteristics of Bax Inhibitor-1 and its Related Diseases
Bax inhibitor-1 (BI-1) is an evolutionarily-conserved endoplasmic reticulum protein. The expression of BI-1 in mammalian cells suppresses apoptosis induced by Bax, a pro-apoptotic member of the Bcl-2 family. BI-1 has been shown to be associated with calcium (Ca(2+)) levels, reactive oxygen species (ROS) production, cytosolic acidification, and autophagy as well as endoplasmic reticulum stress s...
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ژورنال
عنوان ژورنال: Journal of Nippon Medical School
سال: 1997
ISSN: 0048-0444,1884-0108
DOI: 10.1272/jnms1923.64.463